Antiandrogen. III. Oxapregnane Steroids.

Molecular basis for the antiandrogen withdrawal syndrome.

In patients with prostate cancer who manifest disease progression during combined androgen blockade therapy, discontinuation of antiandrogen treatment might result in prostate-specific antigen decline, often associated with clinical improvement. The response called antiandrogen withdrawal syndrome is thus acknowledged as a general phenomenon. However, molecular mechanisms responsible for this s...

Transcortin: a corticosteroid-binding protein of plasma. III. The effects of various steroids.

16-substituted Steroids Iii. the Partial Synthesis of Estriol by Max N. Huffman

Estriol was originally obtained (1930) by isolation from human pregnancy urine by Marrian (1) and by Doisy et al. (2). Both Doisy (2) and Marrian (3) showed that estriol differed from estrone, another estrogenic hormone occurring in gravid urine, in possessing three acetylizable hydroxyl groups instead of the one hydroxyl and one carbonyl. Butenandt (4) soon (1931) proved that estriol might be ...

ARN-509: a novel antiandrogen for prostate cancer treatment.

Continued reliance on the androgen receptor (AR) is now understood as a core mechanism in castration-resistant prostate cancer (CRPC), the most advanced form of this disease. While established and novel AR pathway-targeting agents display clinical efficacy in metastatic CRPC, dose-limiting side effects remain problematic for all current agents. In this study, we report the discovery and develop...

Anabolic steroids.

Athletes, like others, use recreational and lorillicit psychoactive drugs. However, many athletes also use drugs to enhance their training or performance, including an array of bizarre and exotic substances. Although the majority of these substances are not psychoactive, they may be abused by athletes. Some of these substances, such as anabolic steroids and human growth honnone, are referred to...